Acetylated Sodium Hyaluronate-CAS 153987-81-0
Product Name: Acetylated Sodium Hyaluronate
Abbreviation: AcHA
INCI Name: Acetylated Sodium Hyaluronate
CAS No.: 153987-81-0
Grade: Cosmetic Premium Grade (High-end Skincare Special)
Purity: ≥98.0%
Appearance: White or Off-white Fine Powder, Odorless
Molecular Formula: Variable (Acetyl Modified Hyaluronic Acid Salt)
MOQ (Minimum Order Quantity): 25KG
Solubility: Easily soluble in cold and hot water, insoluble in organic solvents; forms transparent and uniform aqueous solution, no agglomeration, excellent compatibility with all water-based skincare systems
Core Efficacy: Dual oil-water affinity super moisturizing, deep skin penetration, long-term water locking, repair damaged skin barrier, anti-oxidation and anti-aging, improve rough and dull skin, enhance skin elasticity and delicacy
Key Characteristics: Unique acetyl hydrophobic modification structure, both water-soluble and lipophilic properties, stronger skin affinity than ordinary HA, high absorption rate, non-sticky texture, long-lasting moisturizing, anti-inflammatory and soothing, stable high and low temperature resistance
Storage Condition: Sealed and stored in dry, cool and ventilated warehouse, avoid high temperature, humidity and direct sunlight, prevent moisture agglomeration, keep tightly sealed after opening to isolate moisture and impurities
Shelf Life: 24 Months
Application: Widely used in high-end moisturizing lotion, essence, facial cream, facial mask, repair skincare products, anti-aging serums, sensitive skin soothing products and functional cosmetic formulas
Acetylated Sodium Hyaluronate, AcHA, Acetylated Hyaluronic Acid Salt, Cosmetic Grade HA Powder, Super Water-locking, Skin Barrier Repair, Anti-aging, High permeability Hyaluronic Acid
Acetylated Sodium Hyaluronate-CAS 153987-81-0
Acetylated Sodium Hyaluronate is a high-end modified hyaluronic acid derivative specially upgraded for high-efficiency skincare, belonging to the new generation of super moisturizing cosmetic functional raw materials. Different from ordinary sodium hyaluronate which only has single water-soluble property, after professional acetylation modification, its molecular chain is grafted with hydrophobic acetyl groups, realizing unique oil-water dual affinity performance.
It perfectly solves the shortcomings of traditional HA such as slow absorption, single surface moisturizing and sticky skin feeling. With excellent lipophilic permeability, it can break through the skin surface barrier, deeply penetrate the dermis layer, supplement and lock skin moisture from the inside out.
Meanwhile, the acetyl modification structure significantly enhances the product's antioxidant activity and skin barrier repair ability, effectively scavenge free radicals, relieve skin redness and dry sensitivity, and inhibit skin aging.
The product has high water solubility, fast dissolution speed, no agglomeration, stable solution performance, fresh and non-sticky skin feeling after use. It is safe, mild and non-irritating, suitable for all skin types including sensitive skin, and is the core star raw material for high-end moisturizing, repair and anti-aging skincare products.



Key Benefits
• Oil-Water Dual Affinity, Stronger Permeability: Unique acetyl hydrophobic modification, both water-soluble and lipophilic, can penetrate lipid barrier efficiently, far better skin absorption and transdermal permeability than ordinary HA.
• Long-Lasting Super Moisturizing, Non-Sticky Feeling: Forms a three-dimensional water-locking protective film on the skin surface, lasting moisturizing for 24 hours, avoids traditional HA sticky and heavy skin feeling, fresh and light texture.
• Efficient Barrier Repair & Soothing: Accelerates the repair of damaged stratum corneum, relieves dryness, redness and sensitivity, improves skin tolerance, and maintains healthy skin barrier state.
• Anti-Oxidation & Anti-Aging, Brighten Skin Tone: Scavenges skin free radicals, inhibits oxidative aging, reduces fine dry lines, fades dullness and yellowish complexion, makes skin bright, tender and elastic.
• Excellent Formula Stability: Resistant to high and low temperature changes, not easy to degrade and inactivate, stable in acidic and neutral formulas, no precipitation or stratification, suitable for complex functional skincare systems.
• Mild & Safe, Wide Adaptability: High-purity cosmetic grade, ultra-low irritation, non-sensitizing, suitable for sensitive skin, pregnant women and weak skin care, compatible with various skincare active ingredients.
Applications
• High-End Moisturizing Essence & Lotion: Core moisturizing and permeable raw material for high-end facial essence, moisturizing toner and nourishing lotion, improve deep moisturizing effect and light skin feeling.
• Barrier Repair Skincare Products: Used in sensitive skin repair essence, soothing cream and postoperative repair skincare, relieve redness and dry sensitivity, repair damaged skin barrier.
• Anti-Aging & Fine Line Firming Products: Added in anti-aging serum, firming cream and wrinkle-resisting skincare products, fade dry lines and fine lines, enhance skin elasticity and compactness.
• Moisturizing & Brightening Facial Mask: Functional additive for facial mask essence, improve skin water content in depth, brighten dull skin, make skin tender and translucent after use.
• Daily Gentle Skincare Series: Suitable for mild moisturizing cream, body lotion and facial care products, long-term moisturizing and skin tendering, improve overall skin texture.
• Custom Functional Skincare Formulas: Compatible with VC, peptides, plant extracts and other active ingredients, used in high-end customized skincare formulas to enhance comprehensive product efficacy.
Certificate Of Analysis (COA)
Test Item | Standard Specification | Test Result |
Product Name | Acetylated Sodium Hyaluronate | Compliant |
CAS No. | 153987-81-0 | Compliant |
Appearance | White or Off-white Fine Powder, Odorless | Compliant |
Purity | ≥98.0% | 98.85% |
Acetylation Degree | ≥3.0% | 3.62% |
Moisture Content | ≤8.0% | 6.15% |
pH Value (1% Solution) | 5.5~7.5 | 6.4 |
Heavy Metal (Pb) | ≤1ppm | 0.2ppm |
Arsenic (As) | ≤0.5ppm | 0.1ppm |
Microorganism | ≤100CFU/g | Qualified |
Conclusion | Conforms to cosmetic grade quality standard | Qualified |
Frequently Asked Questions (FAQ)
• Q1: What is the MOQ of Acetylated Sodium Hyaluronate?
A1: The standard MOQ is 25KG, and sample orders are supported for formula testing and efficacy trial production.
• Q2: What certification documents can be provided?
A2: Complete COA, MSDS, heavy metal and microbial test reports and full set of customs clearance documents are available to support export declaration and cosmetic filing.
• Q3: What is the recommended dosage in skincare formulas?
A3: Conventional addition dosage is 0.05%-0.2% for essence and lotion, 0.1%-0.3% for cream and mask products, adjustable according to moisturizing and repair efficacy requirements.
• Q4: What is the difference between AcHA and ordinary sodium hyaluronate?
A4: Ordinary HA is only water-soluble with single surface moisturizing and sticky feeling; AcHA has oil-water dual affinity, strong transdermal penetration, long-lasting moisturizing, barrier repair and anti-oxidation effects, with lighter and fresher skin feeling.
• Q5: Is the product easy to dissolve and agglomerate?
A5: The powder is fine and uniform, can be quickly dissolved in cold and hot water without agglomeration, the aqueous solution is clear and transparent with stable performance.
• Q6: Is it suitable for sensitive skin and pregnant skincare products?
A6: The product is high-purity, mild and non-irritating, ultra-low heavy metal, no sensitizing ingredients, fully suitable for sensitive skin, pregnant women and weak skin skincare formulas.
• Q7: Do you support stable large-batch supply all year round?
A7: Sufficient factory production capacity ensures continuous, stable and large-volume supply throughout the year to support long-term cooperative orders and customized formula demands.
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